Preparation of submicroparticles based on biodegradable co-polyester

Abstract

The preparation of submicro particles from biodegradable copolyesther by the method of emulsification and solvent evaporation at reduced pressure was investigated. During the study the influence of various process parameters and conditions such as stirring speed, amplitude of sonication and concentration of polymer on the particle diameter and particles size distribution was observed. It was found that it is not possible to achieve a diameter lower than 1 μm without sonication at a relatively high concentration of copolyesther. Without sonication the typical mean diameter ranged from 1-10 μm. On the other hand, sonication enabled to prepare particles with diameter lower than 1 μm. A significant influence of the concentration of polymer on final diameter was found, too.