Stability study of novel medicated hydrogel wound dressings

Abstract

PVP-CMC and PVP-CMC-BA hydrogels were prepared for biomedical applications. These hydrogels were stored under 5°C ± 2°C, 22°C ± 3°C, and 40°C for 180 days to identify their suitable storage condition. At 5°C ± 2°C, hydrogels showed minimum alteration in physical properties. No microbial colonies appeared on PVP-CMC stored at 5°C ± 2°C, but they slowly appeared at 22°C ± 3°C and 40°C after 45 days. FTIR and antibacterial assay demonstrated that boric acid (BA) in hydrogel remained stable for 180 days. PVP-CMC-BA is more bio-stable than PVP-CMC because of BA, an antibacterial agent. Finally, 5°C ± 2°C was recommended as the best storage condition for both PVP-CMC and PVP-CMC-BA hydrogels. © 2013 Copyright Taylor and Francis Group, LLC.