Thermoplastic modification of medical grade polyvinyl chloride with various antibiotics: Effect of antibiotic chemical structure on mechanical, antibacterial properties, and release activity

Abstract

Novel polymeric systems with antibacterial properties based on medical-grade polyvinyl chloride and antibiotics (Ampicillin, Minocycline, and Rifampicin) in the concentrations up to 1 wt% were prepared by thermoplastic compounding. Thermal stability of the antibiotics was corroborated by IR spectroscopy, X-ray diffraction, differential scanning calorimetry, and 1H nuclear magnetic resonance spectroscopy. The effect of chemical structure on mechanical properties of the prepared systems was determined by tensile testing measurements and correlated with optical microscopy observations. In vitro antibacterial properties of samples were determined by agar diffusion and adhesion test against Gramnegative and Gram-positive bacteria. Antibiotic release experiments in distilled water and physiological saline solution and follow-up detecting by Ultraviolet-Visible spectroscopy were carried out. A mathematical model was applied to evaluate the release kinetics of the antibiotics from prepared polymeric systems. © Springer-Verlag 2010.