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Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative

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dc.title Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative en
dc.contributor.author Münster, Lukáš
dc.contributor.author Capáková, Zdenka
dc.contributor.author Humpolíček, Petr
dc.contributor.author Kuřitka, Ivo
dc.contributor.author Christensen, Bjorn Erik
dc.contributor.author Vícha, Jan
dc.relation.ispartof Carbohydrate Polymers
dc.identifier.issn 0144-8617 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2022
utb.relation.volume 292
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.carbpol.2022.119661
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0144861722005665
dc.subject sodium hyaluronate en
dc.subject selective oxidation en
dc.subject periodate oxidation en
dc.subject chlorite oxidation en
dc.subject dicarboxylated hyaluronate en
dc.subject cisplatin en
dc.description.abstract Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of -COOH groups at C2 and C3 carbons of oxidized ?-glucuronic acid units, is investigated. The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties. Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines. DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy. DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1011017
utb.identifier.obdid 43884271
utb.identifier.scopus 2-s2.0-85132290585
utb.identifier.wok 000818379000005
utb.identifier.pubmed 35725164
utb.identifier.coden CAPOD
utb.source j-scopus
dc.date.accessioned 2022-07-13T14:42:38Z
dc.date.available 2022-07-13T14:42:38Z
dc.description.sponsorship RP/CPS/2022/007; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Grantová Agentura České Republiky, GA ČR: 20-28732S, CZ LM2018140, LM2018127
dc.description.sponsorship Ministry of Education, Youth and Sports of the Czech Republic - DKRVO [RP/CPS/2022/007]; Czech Science Foundation grant [20-28732S]; Ministry of Education, Youth and Sports of the Czech Republic [LM2018127, e-INFRA CZ LM2018140]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Münster, Lukáš
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Kuřitka, Ivo
utb.contributor.internalauthor Vícha, Jan
utb.fulltext.affiliation Lukáš Münster a,*, Zdenka Capáková a, Petr Humpolíček a, Ivo Kuřitka a, Bjørn E. Christensen b, Jan Vícha a a Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, 760 01 Zlín, Czech Republic b NOBIPOL, Department of Biotechnology and Food Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway * Corresponding author. E-mail address: [email protected] (L. Münster).
utb.fulltext.dates Received 3 March 2022 Received in revised form 22 April 2022 Accepted 23 May 2022 Available online 27 May 2022
utb.fulltext.sponsorship This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic – DKRVO (RP/CPS/2022/007). Z. Capáková and P. Humpolíček acknowledge the Czech Science Foundation grant (20-28732S). CIISB research infrastructure project LM2018127 funded by the Ministry of Education, Youth and Sports of the Czech Republic is gratefully acknowledged for the financial support of the NMR measurements at the Josef Dadok CEITEC core facility in Brno. Computational resources were supplied by the project “e-Infrastruktura CZ” (e-INFRA CZ LM2018140) supported by the Ministry of Education, Youth and Sports of the Czech Republic.
utb.wos.affiliation [Muenster, Lukas; Capakova, Zdenka; Humpolicek, Petr; Kuritka, Ivo; Vicha, Jan] Tomas Bata Univ Zlin, Ctr Polymer Syst, Tr Tomase Bati 5678, Zlin 76001, Czech Republic; [Christensen, Bjorn E.] Norwegian Univ Sci & Technol NTNU, Dept Biotechnol & Food Sci, NOBIPOL, Trondheim, Norway
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, Zlín, 760 01, Czech Republic; NOBIPOL, Department of Biotechnology and Food Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
utb.fulltext.projects RP/CPS/2022/007
utb.fulltext.projects 20-28732S
utb.fulltext.projects LM2018127
utb.fulltext.projects LM2018140
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
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