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dc.title | Dicarboxylated hyaluronate: Synthesis of a new, highly functionalized and biocompatible derivative | en |
dc.contributor.author | Münster, Lukáš | |
dc.contributor.author | Capáková, Zdenka | |
dc.contributor.author | Humpolíček, Petr | |
dc.contributor.author | Kuřitka, Ivo | |
dc.contributor.author | Christensen, Bjorn Erik | |
dc.contributor.author | Vícha, Jan | |
dc.relation.ispartof | Carbohydrate Polymers | |
dc.identifier.issn | 0144-8617 Scopus Sources, Sherpa/RoMEO, JCR | |
dc.date.issued | 2022 | |
utb.relation.volume | 292 | |
dc.type | article | |
dc.language.iso | en | |
dc.publisher | Elsevier Ltd | |
dc.identifier.doi | 10.1016/j.carbpol.2022.119661 | |
dc.relation.uri | https://www.sciencedirect.com/science/article/pii/S0144861722005665 | |
dc.subject | sodium hyaluronate | en |
dc.subject | selective oxidation | en |
dc.subject | periodate oxidation | en |
dc.subject | chlorite oxidation | en |
dc.subject | dicarboxylated hyaluronate | en |
dc.subject | cisplatin | en |
dc.description.abstract | Sequential periodate-chlorite oxidation of sodium hyaluronate to 2,3-dicarboxylated hyaluronate (DCH), a novel biocompatible and highly functionalized derivative bearing additional pair of -COOH groups at C2 and C3 carbons of oxidized ?-glucuronic acid units, is investigated. The impact of various reaction parameters (time, oxidizer concentration, and molar amount) on DCH's composition, molecular weight, degree of oxidation, and cytotoxicity are investigated to guide the synthesis of DCH derivatives of desired properties. Subsequently, fully (99%) and partially (70%) oxidized DCH derivatives were compared to untreated sodium hyaluronate in terms of anticancer drug cisplatin loading efficacy, carrier capacity, drug release rates, and cytotoxicity towards healthy and cancerous cell lines. DCH derivatives were found to be superior in every aspect, having nearly twice the carrier capacity, significantly slower release rates, and higher efficacy. DCH is thus a highly interesting hyaluronate derivative with an adjustable degree of oxidation, molecular weight, and great potential for further modifications. | en |
utb.faculty | University Institute | |
dc.identifier.uri | http://hdl.handle.net/10563/1011017 | |
utb.identifier.obdid | 43884271 | |
utb.identifier.scopus | 2-s2.0-85132290585 | |
utb.identifier.wok | 000818379000005 | |
utb.identifier.pubmed | 35725164 | |
utb.identifier.coden | CAPOD | |
utb.source | j-scopus | |
dc.date.accessioned | 2022-07-13T14:42:38Z | |
dc.date.available | 2022-07-13T14:42:38Z | |
dc.description.sponsorship | RP/CPS/2022/007; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Grantová Agentura České Republiky, GA ČR: 20-28732S, CZ LM2018140, LM2018127 | |
dc.description.sponsorship | Ministry of Education, Youth and Sports of the Czech Republic - DKRVO [RP/CPS/2022/007]; Czech Science Foundation grant [20-28732S]; Ministry of Education, Youth and Sports of the Czech Republic [LM2018127, e-INFRA CZ LM2018140] | |
utb.ou | Centre of Polymer Systems | |
utb.contributor.internalauthor | Münster, Lukáš | |
utb.contributor.internalauthor | Capáková, Zdenka | |
utb.contributor.internalauthor | Humpolíček, Petr | |
utb.contributor.internalauthor | Kuřitka, Ivo | |
utb.contributor.internalauthor | Vícha, Jan | |
utb.fulltext.affiliation | Lukáš Münster a,*, Zdenka Capáková a, Petr Humpolíček a, Ivo Kuřitka a, Bjørn E. Christensen b, Jan Vícha a a Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, 760 01 Zlín, Czech Republic b NOBIPOL, Department of Biotechnology and Food Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway * Corresponding author. E-mail address: [email protected] (L. Münster). | |
utb.fulltext.dates | Received 3 March 2022 Received in revised form 22 April 2022 Accepted 23 May 2022 Available online 27 May 2022 | |
utb.fulltext.sponsorship | This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic – DKRVO (RP/CPS/2022/007). Z. Capáková and P. Humpolíček acknowledge the Czech Science Foundation grant (20-28732S). CIISB research infrastructure project LM2018127 funded by the Ministry of Education, Youth and Sports of the Czech Republic is gratefully acknowledged for the financial support of the NMR measurements at the Josef Dadok CEITEC core facility in Brno. Computational resources were supplied by the project “e-Infrastruktura CZ” (e-INFRA CZ LM2018140) supported by the Ministry of Education, Youth and Sports of the Czech Republic. | |
utb.wos.affiliation | [Muenster, Lukas; Capakova, Zdenka; Humpolicek, Petr; Kuritka, Ivo; Vicha, Jan] Tomas Bata Univ Zlin, Ctr Polymer Syst, Tr Tomase Bati 5678, Zlin 76001, Czech Republic; [Christensen, Bjorn E.] Norwegian Univ Sci & Technol NTNU, Dept Biotechnol & Food Sci, NOBIPOL, Trondheim, Norway | |
utb.scopus.affiliation | Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, Zlín, 760 01, Czech Republic; NOBIPOL, Department of Biotechnology and Food Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway | |
utb.fulltext.projects | RP/CPS/2022/007 | |
utb.fulltext.projects | 20-28732S | |
utb.fulltext.projects | LM2018127 | |
utb.fulltext.projects | LM2018140 | |
utb.fulltext.faculty | University Institute | |
utb.fulltext.ou | Centre of Polymer Systems |