Polymeric hydrogel based systems for vaccine delivery: A review

Abstract

The appropriate delivery of vaccines is a significant factor for the proper immunization. The proper delivery of the cargo vaccine/antigen along with stimulation of high antigen mediated immune response are the prime factors of an efficient vaccine deliver system. Different delivery systems have been explored for vaccine delivery and immunization. However, significant limitations like inefficient immunogenicity and undesired inflammatory immunogenic reactions are also notable. Thus, the development of an efficient vaccine delivery system is challenging task. Polymer based systems have also been utilized for vaccine delivery. Research also have indicated that a polymeric hydrogel can become an efficient delivery system of foreign antigens and vaccines. These systems can harbor and deliver the cargo vaccine/antigen in desired target organ and also facilitate the antigen mediated immunogenicity. Keeping in view the above perspectives, an attempt has been made to review the significance of polymeric hydrogel based systems for vaccine delivery. © 2021 Elsevier Ltd