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Self-assembly of poly(L-lactide-co-glycolide) and magnetic nanoparticles into nanoclusters for controlled drug delivery

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dc.title Self-assembly of poly(L-lactide-co-glycolide) and magnetic nanoparticles into nanoclusters for controlled drug delivery en
dc.contributor.author Zumaya, Alma Lucia Villela
dc.contributor.author Martynek, Dominik
dc.contributor.author Bautkinová, Tereza
dc.contributor.author Šoóš, Miroslav
dc.contributor.author Ulbrich, Pavel
dc.contributor.author Raquez, Jean-Marie
dc.contributor.author Dendisová, Marcela
dc.contributor.author Merna, Jan
dc.contributor.author Vilčáková, Jarmila
dc.contributor.author Kopecký, Dušan
dc.contributor.author Hassouna, Fatima
dc.relation.ispartof European Polymer Journal
dc.identifier.issn 0014-3057 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2020
utb.relation.volume 133
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.eurpolymj.2020.109795
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0014305720304523
dc.subject PLGA nanoparticles en
dc.subject Iron oxide nanoparticles en
dc.subject Nanoprecipitation en
dc.subject Self-assembly en
dc.subject Electrostatic interactions en
dc.subject Heteroclusters en
dc.subject Dissolution tests en
dc.description.abstract The possibility to combine nanoparticles (NPs) with different functionalities into nanoclusters of controlled size and kinetic profile of drug release presents a promising route for the preparation of a multifunctional drug delivery system. In this study, to construct controlled drug delivery (nano)clusters, a simple and versatile method based on self-assembly via electrostatic interactions of oppositely charged poly(lactide-co-glycolide) (PLGA) and superparamagnetic iron oxide (IO) NPs was developed. Drug loaded heteroclusters with controlled size of 224 ± 52 nm and Zeta potential of −51 ± 6 mV were produced. Dissolution tests demonstrated an accelerated drug release in the heteroclusters compared to neat PLGA NPs after 24 h. This was correlated with the catalytic effect of IO NPs on the degradation of PLGA matrix. Moreover, the magnetic properties of the heteroclusters were maintained after the dissolution tests. Hence, even after drug release, the heteroclusters can be used for treatment with magnetically mediated hyperthermia. © 2020 Elsevier Ltd en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1009723
utb.identifier.obdid 43881921
utb.identifier.scopus 2-s2.0-85085490935
utb.identifier.wok 000549179400006
utb.identifier.coden EUPJA
utb.source j-scopus
dc.date.accessioned 2020-06-24T08:32:13Z
dc.date.available 2020-06-24T08:32:13Z
dc.description.sponsorship Ministry of Health of the Czech RepublicMinistry of Health, Czech Republic [AZV 16-34342A]; specific university research grant [A2_FCHI_2020_031]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Vilčáková, Jarmila
utb.fulltext.affiliation Alma Lucia Villela Zumaya a, Dominik Martynek a, Tereza Bautkinová a, Miroslav Šoóš a*, Pavel Ulbrich b, Jean-Marie Raquez c, Marcela Dendisová d, Jan Merna e, Jarmila Vilčáková f, Dušan Kopecký g, Fatima Hassouna a* a Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic b Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic c Laboratory of Polymeric and Composite Materials, University of Mons (UMONS), Place du Parc 20, 7000 Mons, Belgium d Department of Physical Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic e Department of Polymers, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic f Centre of Polymer Systems, Tomas Bata University in Zlin, tř. T. Bati 5678, Zlin 760 01, Czech Republic g Department of Computing and Control Engineering, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic ⁎ Corresponding authors. E-mail addresses: [email protected] (M. Šoóš), [email protected] (F. Hassouna).
utb.fulltext.dates Received 25 February 2020 Received in revised form 7 May 2020 Accepted 22 May 2020 Available online 23 May 2020
utb.fulltext.sponsorship The authors would like to acknowledge the funding by the grant of Ministry of Health of the Czech Republic ( AZV 16-34342A ) and the specific university research grant (A2_FCHI_2020_031). Jean-Marie Raquez is a FRS- FNRS research associate. The authors would like to acknowledge Mr. Xavier Carette for assistance in the laboratory and Dr. Rosica Mincheva for the fruitfull discussions.
utb.wos.affiliation [Zumaya, Alma Lucia Villela; Martynek, Dominik; Bautkinova, Tereza; Soos, Miroslav; Hassouna, Fatima] Univ Chem & Technol, Dept Chem Engn, Tech 5, Prague 16628 6, Czech Republic; [Ulbrich, Pavel] Univ Chem & Technol Prague, Dept Biochem & Microbiol, Tech 5, Prague 16628 6, Czech Republic; [Raquez, Jean-Marie] Univ Mons UMONS, Lab Polymer & Composite Mat, Pl Parc 20, B-7000 Mons, Belgium; [Dendisova, Marcela] Univ Chem & Technol Prague, Dept Phys Chem, Tech 5, Prague 16628 6, Czech Republic; [Merna, Jan] Univ Chem & Technol Prague, Dept Polymers, Tech 5, Prague 16628 6, Czech Republic; [Vilcakova, Jarmila] Tomas Bata Univ Zlin, Ctr Polymer Syst, Tr T Bati 5678, Zlin 76001, Czech Republic; [Kopecky, Dusan] Univ Chem & Technol Prague, Dept Comp & Control Engn, Tech 5, Prague 16628 6, Czech Republic
utb.scopus.affiliation Department of Chemical Engineering, University Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; Laboratory of Polymeric and Composite Materials, University of Mons (UMONS), Place du Parc 20, Mons, 7000, Belgium; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic; Department of Computing and Control Engineering, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic; Department of Physical Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic; Department of Polymers, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic; Centre of Polymer Systems, Tomas Bata University in Zlin, tř. T. Bati 5678, Zlin, 760 01, Czech Republic
utb.fulltext.projects AZV 16-34342A
utb.fulltext.projects A2_FCHI_2020_031
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
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