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dc.title | Self-assembly of poly(L-lactide-co-glycolide) and magnetic nanoparticles into nanoclusters for controlled drug delivery | en |
dc.contributor.author | Zumaya, Alma Lucia Villela | |
dc.contributor.author | Martynek, Dominik | |
dc.contributor.author | Bautkinová, Tereza | |
dc.contributor.author | Šoóš, Miroslav | |
dc.contributor.author | Ulbrich, Pavel | |
dc.contributor.author | Raquez, Jean-Marie | |
dc.contributor.author | Dendisová, Marcela | |
dc.contributor.author | Merna, Jan | |
dc.contributor.author | Vilčáková, Jarmila | |
dc.contributor.author | Kopecký, Dušan | |
dc.contributor.author | Hassouna, Fatima | |
dc.relation.ispartof | European Polymer Journal | |
dc.identifier.issn | 0014-3057 Scopus Sources, Sherpa/RoMEO, JCR | |
dc.date.issued | 2020 | |
utb.relation.volume | 133 | |
dc.type | article | |
dc.language.iso | en | |
dc.publisher | Elsevier Ltd | |
dc.identifier.doi | 10.1016/j.eurpolymj.2020.109795 | |
dc.relation.uri | https://www.sciencedirect.com/science/article/pii/S0014305720304523 | |
dc.subject | PLGA nanoparticles | en |
dc.subject | Iron oxide nanoparticles | en |
dc.subject | Nanoprecipitation | en |
dc.subject | Self-assembly | en |
dc.subject | Electrostatic interactions | en |
dc.subject | Heteroclusters | en |
dc.subject | Dissolution tests | en |
dc.description.abstract | The possibility to combine nanoparticles (NPs) with different functionalities into nanoclusters of controlled size and kinetic profile of drug release presents a promising route for the preparation of a multifunctional drug delivery system. In this study, to construct controlled drug delivery (nano)clusters, a simple and versatile method based on self-assembly via electrostatic interactions of oppositely charged poly(lactide-co-glycolide) (PLGA) and superparamagnetic iron oxide (IO) NPs was developed. Drug loaded heteroclusters with controlled size of 224 ± 52 nm and Zeta potential of −51 ± 6 mV were produced. Dissolution tests demonstrated an accelerated drug release in the heteroclusters compared to neat PLGA NPs after 24 h. This was correlated with the catalytic effect of IO NPs on the degradation of PLGA matrix. Moreover, the magnetic properties of the heteroclusters were maintained after the dissolution tests. Hence, even after drug release, the heteroclusters can be used for treatment with magnetically mediated hyperthermia. © 2020 Elsevier Ltd | en |
utb.faculty | University Institute | |
dc.identifier.uri | http://hdl.handle.net/10563/1009723 | |
utb.identifier.obdid | 43881921 | |
utb.identifier.scopus | 2-s2.0-85085490935 | |
utb.identifier.wok | 000549179400006 | |
utb.identifier.coden | EUPJA | |
utb.source | j-scopus | |
dc.date.accessioned | 2020-06-24T08:32:13Z | |
dc.date.available | 2020-06-24T08:32:13Z | |
dc.description.sponsorship | Ministry of Health of the Czech RepublicMinistry of Health, Czech Republic [AZV 16-34342A]; specific university research grant [A2_FCHI_2020_031] | |
utb.ou | Centre of Polymer Systems | |
utb.contributor.internalauthor | Vilčáková, Jarmila | |
utb.fulltext.affiliation | Alma Lucia Villela Zumaya a, Dominik Martynek a, Tereza Bautkinová a, Miroslav Šoóš a*, Pavel Ulbrich b, Jean-Marie Raquez c, Marcela Dendisová d, Jan Merna e, Jarmila Vilčáková f, Dušan Kopecký g, Fatima Hassouna a* a Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic b Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic c Laboratory of Polymeric and Composite Materials, University of Mons (UMONS), Place du Parc 20, 7000 Mons, Belgium d Department of Physical Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic e Department of Polymers, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic f Centre of Polymer Systems, Tomas Bata University in Zlin, tř. T. Bati 5678, Zlin 760 01, Czech Republic g Department of Computing and Control Engineering, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic ⁎ Corresponding authors. E-mail addresses: [email protected] (M. Šoóš), [email protected] (F. Hassouna). | |
utb.fulltext.dates | Received 25 February 2020 Received in revised form 7 May 2020 Accepted 22 May 2020 Available online 23 May 2020 | |
utb.fulltext.sponsorship | The authors would like to acknowledge the funding by the grant of Ministry of Health of the Czech Republic ( AZV 16-34342A ) and the specific university research grant (A2_FCHI_2020_031). Jean-Marie Raquez is a FRS- FNRS research associate. The authors would like to acknowledge Mr. Xavier Carette for assistance in the laboratory and Dr. Rosica Mincheva for the fruitfull discussions. | |
utb.wos.affiliation | [Zumaya, Alma Lucia Villela; Martynek, Dominik; Bautkinova, Tereza; Soos, Miroslav; Hassouna, Fatima] Univ Chem & Technol, Dept Chem Engn, Tech 5, Prague 16628 6, Czech Republic; [Ulbrich, Pavel] Univ Chem & Technol Prague, Dept Biochem & Microbiol, Tech 5, Prague 16628 6, Czech Republic; [Raquez, Jean-Marie] Univ Mons UMONS, Lab Polymer & Composite Mat, Pl Parc 20, B-7000 Mons, Belgium; [Dendisova, Marcela] Univ Chem & Technol Prague, Dept Phys Chem, Tech 5, Prague 16628 6, Czech Republic; [Merna, Jan] Univ Chem & Technol Prague, Dept Polymers, Tech 5, Prague 16628 6, Czech Republic; [Vilcakova, Jarmila] Tomas Bata Univ Zlin, Ctr Polymer Syst, Tr T Bati 5678, Zlin 76001, Czech Republic; [Kopecky, Dusan] Univ Chem & Technol Prague, Dept Comp & Control Engn, Tech 5, Prague 16628 6, Czech Republic | |
utb.scopus.affiliation | Department of Chemical Engineering, University Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; Laboratory of Polymeric and Composite Materials, University of Mons (UMONS), Place du Parc 20, Mons, 7000, Belgium; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic; Department of Computing and Control Engineering, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic; Department of Physical Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic; Department of Polymers, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic; Centre of Polymer Systems, Tomas Bata University in Zlin, tř. T. Bati 5678, Zlin, 760 01, Czech Republic | |
utb.fulltext.projects | AZV 16-34342A | |
utb.fulltext.projects | A2_FCHI_2020_031 | |
utb.fulltext.faculty | University Institute | |
utb.fulltext.ou | Centre of Polymer Systems |