In vivo monitoring of tumor distribution of hyaluronan polymeric micelles labeled or loaded with near-infrared fluorescence dye

Achbergerová, Eva; Šmejkalová, Daniela; Huerta-Angeles, Gloria; Souček, Karel; Hermannová, Martina; Vágnerová, Hana; Vícha, Robert; Velebný, Vladimír

dc.title	In vivo monitoring of tumor distribution of hyaluronan polymeric micelles labeled or loaded with near-infrared fluorescence dye	en
dc.contributor.author	Achbergerová, Eva
dc.contributor.author	Šmejkalová, Daniela
dc.contributor.author	Huerta-Angeles, Gloria
dc.contributor.author	Souček, Karel
dc.contributor.author	Hermannová, Martina
dc.contributor.author	Vágnerová, Hana
dc.contributor.author	Vícha, Robert
dc.contributor.author	Velebný, Vladimír
dc.relation.ispartof	Carbohydrate Polymers
dc.identifier.issn	0144-8617 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued	2018
utb.relation.volume	198
dc.citation.spage	339
dc.citation.epage	347
dc.type	article
dc.language.iso	en
dc.publisher	Elsevier
dc.identifier.doi	10.1016/j.carbpol.2018.06.082
dc.relation.uri	https://www.sciencedirect.com/science/article/pii/S0144861718307367
dc.subject	Hyaluronan	en
dc.subject	Polymeric micelles	en
dc.subject	NIR fluorescence imaging	en
dc.subject	Tumor detection	en
dc.description.abstract	Development of delivery systems which allow real-time visual inspection of tumors is critical for effective therapy. Near-infrared (NIR) fluorophores have a great potential for such an application. To overcome NIR dyes short blood circulation time and increase tumor accumulation, a NIR dye, cypate, was associated with oleyl hyaluronan, which can self-assemble into polymeric aggregates. The cypate association with oleyl hyaluronan was performed either by a covalent linkage, or physical entrapment. The two systems were compared for tumor targeting and contrast enhancement using BALB/c mice bearing 4T1 breast cancer tumors. Independently on the way of cypate association, it took more than 24 h from intravenous administration to detect NIR signal in tumors and the tumors were clearly visualized for 2 following weeks without substrate reinjection. Covalently linked cypate generated 2–3 fold stronger fluorescence signal than physically loaded cypate. This study demonstrates the potential of HA matrix to be used as carrier of contrast agents for non-invasive long-term tumor visualization. © 2018 Elsevier Ltd	en
utb.faculty	Faculty of Technology
dc.identifier.uri	http://hdl.handle.net/10563/1008081
utb.identifier.obdid	43878229
utb.identifier.scopus	2-s2.0-85049036699
utb.identifier.wok	000440785200040
utb.identifier.pubmed	30093008
utb.identifier.coden	CAPOD
utb.source	j-scopus
dc.date.accessioned	2018-07-27T08:47:42Z
dc.date.available	2018-07-27T08:47:42Z
dc.description.sponsorship	MEYS, Ministry of Education, Youth and Science
dc.description.sponsorship	Internal Founding Agency of Tomas Bata University in Zlin [IGA/FT/2018/001]; National Program of Sustainability II (MEYS CR) [LQ1605]; program Institute Contipro
utb.contributor.internalauthor	Achbergerová, Eva
utb.contributor.internalauthor	Vícha, Robert
utb.fulltext.affiliation	Eva Achbergerová a,b , Daniela Šmejkalová a,* , Gloria Huerta-Angeles a , Karel Souček c,d,e , Martina Hermannová a , Hana Vágnerová a , Robert Vícha b , Vladimír Velebný a a Contipro a.s., Dolní Dobrouč 401, Dolní Dobrouč, 561 02, Czech Republic b Department of Chemistry, Faculty of Technology, Tomas Bata University in Zlín, Vavrečkova 275, 760 01, Zlín, Czech Republic c The Czech Academy of Sciences, Institute of Biophysics, Královopolská 135, 612 65, Brno, Czech Republic d International Clinical Research Center, St. Anne's University Hospital, Pekařská 53, 656 91 Brno, Czech Republic e Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 735/5, 625 00 Brno, Czech Republic * Corresponding author. E-mail address: [email protected] (D. Šmejkalová).
utb.fulltext.dates	Received 13 March 2018 Received in revised form 11 June 2018 Accepted 18 June 2018 Available online 22 June 2018
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utb.fulltext.sponsorship	This work was financially supported by the Internal Founding Agency of Tomas Bata University in Zlín [Project No. IGA/FT/2018/001], by project LQ1605 from the National Program of Sustainability II (MEYS CR), and the program Institute Contipro. Our thanks go also to Pavla Řezníčková and Dr. Nina Charvátová for maintenance of animal facility.
utb.wos.affiliation	[Achbergerova, Eva; Smejkalova, Daniela; Huerta-Angeles, Gloria; Hermannova, Martina; Vagnerova, Hana; Velebny, Vladimir] Contipro As, Dolni Dobrouc 401, Dolni Dobrouc 56102, Czech Republic; [Achbergerova, Eva; Vicha, Robert] Tomas Bata Univ Zlin, Fac Technol, Dept Chem, Vavreckova 275, Zlin 76001, Czech Republic; [Soucek, Karel] Czech Acad Sci, Inst Biophys, Kralovopolska 135, Brno 61265, Czech Republic; [Soucek, Karel] St Annes Univ Hosp, Int Clin Res Ctr, Pekarska 53, Brno 65691, Czech Republic; [Soucek, Karel] Masaryk Univ, Fac Sci, Dept Expt Biol, Kamenice 735-5, Brno 62500, Czech Republic
utb.scopus.affiliation	Contipro a.s., Dolní Dobrouč 401, Dolní Dobrouč, Czech Republic; Department of Chemistry, Faculty of Technology, Tomas Bata University in Zlín, Vavrečkova 275, Zlín, Czech Republic; The Czech Academy of Sciences, Institute of Biophysics, Královopolská 135, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Pekařská 53, Brno, Czech Republic; Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 735/5, Brno, Czech Republic
utb.fulltext.projects	IGA/FT/2018/001
utb.fulltext.projects	LQ1605