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Vaginal use of micronized progesterone for luteal support. A randomized study comparing utrogestan® and crinone® 8%

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dc.title Vaginal use of micronized progesterone for luteal support. A randomized study comparing utrogestan® and crinone® 8% en
dc.contributor.author Michnová, Lucie
dc.contributor.author Dostál, Jiří
dc.contributor.author Kudela, Milan
dc.contributor.author Hamal, Petr
dc.contributor.author Langová, Kateřina
dc.relation.ispartof Biomedical Papers
dc.identifier.issn 1213-8118 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2017
utb.relation.volume 161
utb.relation.issue 1
dc.citation.spage 86
dc.citation.epage 91
dc.type article
dc.language.iso en
dc.publisher Univerzita Palackého v Olomouci
dc.identifier.doi 10.5507/bp.2017.007
dc.relation.uri http://biomed.papers.upol.cz/artkey/bio-201701-0012_Vaginal_use_of_micronized_progesterone_for_luteal_support_A_randomized_study_comparing_Utrogestan_174_and_Cri.php
dc.subject luteal phase support en
dc.subject IVF/ET en
dc.subject Progesterone en
dc.subject Utrogestan en
dc.subject Crinone 8% en
dc.description.abstract Background and Objective. Luteal phase physiology is distorted by in vitro fertilization (IVF) cycles using gonadotropin-releasing hormone (GnRH) agonists and antagonists, Controlled ovarian hyperstimulation leads to luteal phase defect and for this reason, luteal phase support is now an integral part of IVF/ICSI-ET programs. The support is provided by hCG, progesterone or GnRH-a. This study compared the efficiency, safety and tolerance of two vaginal micronized progesterones, Utrogestan and Crinone 8%. Methods. 111 women, 18-40 years old, FSH < 10 IU/L and normal uterus findings were included. The efficiency of the two preparations to provide luteal support was evaluated by the fertilization, implantation, pregnancy and take-home baby rates. The safety was compared through the results of vaginal findings and vaginal inflammation markers before and after treatment. Comparison of tolerance was made by evaluating 21 subjective patient questionnaire parameters. Results. There were no significant differences between the preparations in terms of efficiency or safety though Crinone 8% was better tolerated. Conclusion. The outcomes of this study suggest that a vaginal gel with micronized progesterone (Crinone 8%) is the optimal choice at this time for luteal support. © 2017, PALACKY UNIV. All rights reserved. en
utb.faculty Faculty of Humanities
dc.identifier.uri http://hdl.handle.net/10563/1007160
utb.identifier.obdid 43876469
utb.identifier.scopus 2-s2.0-85016282063
utb.identifier.wok 000398093500013
utb.identifier.pubmed 28323291
utb.source j-scopus
dc.date.accessioned 2017-08-01T08:27:23Z
dc.date.available 2017-08-01T08:27:23Z
dc.rights Attribution 3.0 Unported
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.rights.access openAccess
utb.contributor.internalauthor Kudela, Milan
utb.fulltext.affiliation Lucie Michnova a , Jiri Dostal b , Milan Kudela b,c , Petr Hamal d , Katerina Langova e a IVF Clinic Olomouc, Horni Lan 6, Olomouc, Czech Republic b Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic c Department of Health Care Sciences, Faculty of Humanities, Thomas Bata University in Zlin, Czech Republic d Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic e Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic Corresponding author: Lucie Michnova, e-mail: [email protected]
utb.fulltext.dates Received: November 4, 2016; Accepted: February 24, 2017; Available online: March 14, 2017
utb.fulltext.sponsorship The study was made at the academical department without any pharmaceutical company contributions or other financial supports.
utb.wos.affiliation [Michnova, Lucie] IVF Clin Olomouc, HorniLan 6, Olomouc, Czech Republic; [Dostal, Jiri; Kudela, Milan] Palacky Univ Olomouc, Fac Med & Dent, Dept Obstet & Ginecol, Olomouc, Czech Republic; [Kudela, Milan] Thomas Bata Univ Zlin, Fac Humanities, Dept Hlth Care Sci, Zlin, Czech Republic; [Hamal, Petr] Palacky Univ Olomouc, Fac Med & Dent, Dept Microbiol, Olomouc, Czech Republic; [Langova, Katerina] Palacky Univ Olomouc, Fac Med & Dent, Dept Med Biophys, Olomouc, Czech Republic
utb.scopus.affiliation Michnova, L., IVF Clinic Olomouc, Horni Lan 6, Olomouc, Czech Republic; Dostal, J., Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Kudela, M., Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, Department of Health Care Sciences, Faculty of Humanities, Thomas Bata University, Zlin, Czech Republic; Hamal, P., Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Langova, K., Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
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