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dc.title | Vaginal use of micronized progesterone for luteal support. A randomized study comparing utrogestan® and crinone® 8% | en |
dc.contributor.author | Michnová, Lucie | |
dc.contributor.author | Dostál, Jiří | |
dc.contributor.author | Kudela, Milan | |
dc.contributor.author | Hamal, Petr | |
dc.contributor.author | Langová, Kateřina | |
dc.relation.ispartof | Biomedical Papers | |
dc.identifier.issn | 1213-8118 Scopus Sources, Sherpa/RoMEO, JCR | |
dc.date.issued | 2017 | |
utb.relation.volume | 161 | |
utb.relation.issue | 1 | |
dc.citation.spage | 86 | |
dc.citation.epage | 91 | |
dc.type | article | |
dc.language.iso | en | |
dc.publisher | Univerzita Palackého v Olomouci | |
dc.identifier.doi | 10.5507/bp.2017.007 | |
dc.relation.uri | http://biomed.papers.upol.cz/artkey/bio-201701-0012_Vaginal_use_of_micronized_progesterone_for_luteal_support_A_randomized_study_comparing_Utrogestan_174_and_Cri.php | |
dc.subject | luteal phase support | en |
dc.subject | IVF/ET | en |
dc.subject | Progesterone | en |
dc.subject | Utrogestan | en |
dc.subject | Crinone 8% | en |
dc.description.abstract | Background and Objective. Luteal phase physiology is distorted by in vitro fertilization (IVF) cycles using gonadotropin-releasing hormone (GnRH) agonists and antagonists, Controlled ovarian hyperstimulation leads to luteal phase defect and for this reason, luteal phase support is now an integral part of IVF/ICSI-ET programs. The support is provided by hCG, progesterone or GnRH-a. This study compared the efficiency, safety and tolerance of two vaginal micronized progesterones, Utrogestan and Crinone 8%. Methods. 111 women, 18-40 years old, FSH < 10 IU/L and normal uterus findings were included. The efficiency of the two preparations to provide luteal support was evaluated by the fertilization, implantation, pregnancy and take-home baby rates. The safety was compared through the results of vaginal findings and vaginal inflammation markers before and after treatment. Comparison of tolerance was made by evaluating 21 subjective patient questionnaire parameters. Results. There were no significant differences between the preparations in terms of efficiency or safety though Crinone 8% was better tolerated. Conclusion. The outcomes of this study suggest that a vaginal gel with micronized progesterone (Crinone 8%) is the optimal choice at this time for luteal support. © 2017, PALACKY UNIV. All rights reserved. | en |
utb.faculty | Faculty of Humanities | |
dc.identifier.uri | http://hdl.handle.net/10563/1007160 | |
utb.identifier.obdid | 43876469 | |
utb.identifier.scopus | 2-s2.0-85016282063 | |
utb.identifier.wok | 000398093500013 | |
utb.identifier.pubmed | 28323291 | |
utb.source | j-scopus | |
dc.date.accessioned | 2017-08-01T08:27:23Z | |
dc.date.available | 2017-08-01T08:27:23Z | |
dc.rights | Attribution 3.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.rights.access | openAccess | |
utb.contributor.internalauthor | Kudela, Milan | |
utb.fulltext.affiliation | Lucie Michnova a , Jiri Dostal b , Milan Kudela b,c , Petr Hamal d , Katerina Langova e a IVF Clinic Olomouc, Horni Lan 6, Olomouc, Czech Republic b Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic c Department of Health Care Sciences, Faculty of Humanities, Thomas Bata University in Zlin, Czech Republic d Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic e Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic Corresponding author: Lucie Michnova, e-mail: [email protected] | |
utb.fulltext.dates | Received: November 4, 2016; Accepted: February 24, 2017; Available online: March 14, 2017 | |
utb.fulltext.sponsorship | The study was made at the academical department without any pharmaceutical company contributions or other financial supports. | |
utb.wos.affiliation | [Michnova, Lucie] IVF Clin Olomouc, HorniLan 6, Olomouc, Czech Republic; [Dostal, Jiri; Kudela, Milan] Palacky Univ Olomouc, Fac Med & Dent, Dept Obstet & Ginecol, Olomouc, Czech Republic; [Kudela, Milan] Thomas Bata Univ Zlin, Fac Humanities, Dept Hlth Care Sci, Zlin, Czech Republic; [Hamal, Petr] Palacky Univ Olomouc, Fac Med & Dent, Dept Microbiol, Olomouc, Czech Republic; [Langova, Katerina] Palacky Univ Olomouc, Fac Med & Dent, Dept Med Biophys, Olomouc, Czech Republic | |
utb.scopus.affiliation | Michnova, L., IVF Clinic Olomouc, Horni Lan 6, Olomouc, Czech Republic; Dostal, J., Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Kudela, M., Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic, Department of Health Care Sciences, Faculty of Humanities, Thomas Bata University, Zlin, Czech Republic; Hamal, P., Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Langova, K., Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic |