Phenolic compounds from allium schoenoprasum, tragopogon pratensis and rumex acetosa and their antiproliferative effects

Kuceková, Zdenka; Mlček, Jiří; Humpolíček, Petr; Rop, Otakar; Valášek, Pavel; Sáha, Petr

dc.title	Phenolic compounds from allium schoenoprasum, tragopogon pratensis and rumex acetosa and their antiproliferative effects	en
dc.contributor.author	Kuceková, Zdenka
dc.contributor.author	Mlček, Jiří
dc.contributor.author	Humpolíček, Petr
dc.contributor.author	Rop, Otakar
dc.contributor.author	Valášek, Pavel
dc.contributor.author	Sáha, Petr
dc.relation.ispartof	Molecules
dc.identifier.issn	1420-3049 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued	2011
utb.relation.volume	16
utb.relation.issue	11
dc.citation.spage	9207
dc.citation.epage	9217
dc.type	article
dc.language.iso	en
dc.identifier.doi	10.3390/molecules16119207
dc.relation.uri	http://www.mdpi.com/1420-3049/16/11/9207/
dc.subject	allium schoenoprasum	en
dc.subject	HaCaT	en
dc.subject	phenolic compounds	en
dc.subject	proliferation	en
dc.subject	rumex acetosa	en
dc.subject	tragopogon pratensis	en
dc.description.abstract	Experimental studies have shown that phenolic compounds have antiproliferative and tumour arresting effects. The aim of this original study was to investigate the content of phenolic compounds (PhC) in flowers of Allium schoenoprasum (chive), Tragopogon pratensis (meadow salsify) and Rumex acetosa (common sorrel) and their effect on proliferation of HaCaT cells. Antiproliferative effects were evaluated in vitro using the following concentrations of phenolic compounds in cultivation medium: 100, 75, 50 and 25 ÎĽg/mL. Phenolic composition was also determined by HPLC. The results indicate that even low concentrations of these flowers' phenolic compounds inhibited cell proliferation significantly and the possible use of the studied herb's flowers as sources of active phenolic compounds for human nutrition. Â© 2011 by the authors; licensee MDPI, Basel, Switzerland.	en
utb.faculty	Faculty of Technology
utb.faculty	University Institute
dc.identifier.uri	http://hdl.handle.net/10563/1002634
utb.identifier.rivid	RIV/70883521:28110/11:43865483!RIV12-MSM-28110___
utb.identifier.rivid	RIV/70883521:28610/11:43865483!RIV12-MSM-28610___
utb.identifier.obdid	43865494
utb.identifier.scopus	2-s2.0-82255164524
utb.identifier.wok	000297697200024
utb.identifier.coden	MOLEF
utb.source	j-scopus
dc.date.accessioned	2012-02-10T13:15:20Z
dc.date.available	2012-02-10T13:15:20Z
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/3.0/
dc.rights.access	openAccess
utb.ou	Centre of Polymer Systems
utb.contributor.internalauthor	Kuceková, Zdenka
utb.contributor.internalauthor	Mlček, Jiří
utb.contributor.internalauthor	Humpolíček, Petr
utb.contributor.internalauthor	Rop, Otakar
utb.contributor.internalauthor	Valášek, Pavel
utb.contributor.internalauthor	Sáha, Petr
utb.fulltext.affiliation	Zdenka Kucekova 1, Jiri Mlcek 2, Petr Humpolicek 1,3,, Otakar Rop 2, Pavel Valasek 3 and Petr Saha 3 1 Polymer Centre, Faculty of Technology, Tomas Bata University at Zlin, T.G.M. sq. 275, 762 72, Zlin, Czech Republic; E-Mail: [email protected] (Z.K.) 2 Department of Food Technology and Microbiology, Faculty of Technology, Tomas Bata University at Zlin, T.G.M. sq. 275, 762 72 Zlin, Czech Republic; E-Mails: [email protected] (J.M.); [email protected] (O.R.) 3 Centre for Polymer Systems, Polymer Centre, Tomas Bata University at Zlin, T.G.M. sq. 5555, 760 05 Zlin, Czech Republic; E-Mails: [email protected] (P.V.); [email protected] (P.S.) Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +420-576-038-035; Fax: +420-576-031-444.
utb.fulltext.dates	Received: 29 August 2011 in revised form: 21 October 2011 Accepted: 26 October 2011 Published: 3 November 2011
utb.fulltext.references	1. Katiyar, S.K.; Agarwal, R.; Mukhtar, H. Protective effects of green tea polyphenols administered by oral intubation against chemical carcinogen-induced forestomach and pulmonary neoplasia in A/J mice. Cancer Lett. 1993, 73, 167-172. 2. Sharif, T.; Auger, C.; Alhosin, M.; Ebel, C.; Achour, M.; Etienne-Selloum, N.; Fuhrmann, G.; Bronner, C.; Schini-Kerth, V.B. Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redoxsensitive up-regulation of p73 and down-regulation of UHRF1. Eur. J. Cancer 2010, 46, 983-994. 3. Luceri, C.; Caderni, G.; Sanna, A.; Dolara, P. Red Wine and Black Tea Polyphenols Modulate the Expression of Cycloxygenase-2, Inducible Nitric Oxide Synthase and Glutathione-Related Enzymes in Azoxymethane-Induced F344 Rat Colon Tumors. J. Nutr. 2002, 132, 1376-1379. 4. Iwasawa, H.; Morita, E.; Yui, S.; Yamazaki, M. Anti-oxidant Effects of Kiwi Fruit in Vitro and in Vivo. Biol. Pharm. Bull. 2011, 34, 128-134. 5. Rop, O.; Sochor, J.; Jurikova, T.; Zitka, O.; Skutkova, H.; Mlcek, J.; Salas, P.; Krska, B.; Babula, P.; Adam, V.; Kramarova, D.; Beklova, M.; Provaznik, I.; Kizek, R. Effect of five different stages of ripening on chemical compounds in medlar (Mespilus germanica L.). Molecules 2011, 16, 74-91. 6. Kuroda, Y.; Hara, Y. Antimutagenic and anticarcinogenic activity of tea polyphenols. Mutat. Res. 1999, 436, 69-97. 7. Castillo-Pichardo, L.; Martínez-Montemayor, M.M.; Martínez J.E.; Wall, K.M.; Cubano, L.A.; Dharmawardhane, S. Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Clin. Exp. Metastasis 2009, 26, 505-516. 8. Jin, H.; Tan, X.; Liu, X.; Ding, Y. The Study of Effect of Tea Polyphenols on Microsatellite Instability Colorectal Cancer and Its Molecular Mechanism. Int. J. Colorectal Dis. 2010, 25, 1407-1415. 9. Mlček, J.; Rop, O. Fresh edible flowers of ornamental plants—A new source of nutraceutical foods. Trends Food Sci. Tech. 2011, In Press. 10. Rop, O.; Mlček, J.; Juríková, T.; Valšíková, M.; Sochor, J.; Reznicek, V.; Kramarova, D. Phenolic content, antioxidant capacity, radical oxygen species scavenging and lipid peroxidation inhibiting activities of extracts of five black chokeberry (Aronia melanocarpa (Michx.) Elliot) cultivars. J. Med. Plants Res. 2010, 4, 2431-2437. 11. Walter, A.; Etienne-Selloum, N.; Sarr, M.; Kane, M.O.; Beretz, A.; Schini-Kerth, V.B. Angiotensin II induces the vascular expression of VEGF and MMP-2 in vivo: Preventive effect of red wine polyphenols. J. Vasc. Res. 2008, 45, 386-394. 12. Schlachterman, A.; Valle, F.; Wall, K.M.; Azios, N.G.; Castillo, L.; Morell, L.; Washington, A.V.; Cubano, L.A.; Dharmawardhane, S.F. Combined Resveratrol, Quercetin, and Catechin Treatment Reduces Breast Tumor Growth in a Nude Mouse Model. Transl. Oncol. 2008, 1, 19-27. 13. Oak, M.H.; El Bedoui, J.; Schini-Kerth, V.B. Antiangiogenic properties of natural polyphenols from red wine and green tea. J. Nutr. Biochem. 2005, 16, 1-8. 14. Harris, D.M.; Besselink, E.; Henning, S.M.; Go, V.L.; Heber, D. Phytoestrogens induce differential estrogen receptor alpha- or beta-mediated responses in transfected breast cancer cells. Exp. Biol. Med. 2005, 230, 558-568. 15. Roussou, I.; Lambropoulos, I.; Pagoulatos, G.N.; Roussis, I.G. Decrease of heat shock protein levels in hela tumor cells by red wine extracts. Ital. J. Food Sci. 2004, 16, 381-386. 16. Lin, J.K.; Liang, Y.C.; Lin-Shiau, S.Y. Cancer Chemoprevention by Tea Polyphenols through Mitotic Signal Transduction Blockade. Biochem. Pharmacol. 1999, 58, 911-915. 17. Soleas, G.J.; Grass, L.; Josephy, P.D.; Goldberg, D.M.; Diamandis, E.P. A comparison of the anticarcinogenic properties of four red wine polyphenols. Clin. Biochem. 2002, 35, 119-124. 18. Nichenametla, S.N.; Taruscio, T.G.; Barney, D.L.; Exon, J.H. A Review of the Effects and Mechanisms of Polyphenolics in Cancer. Crit. Rev. Food Sci. 2006, 46, 161-183. 19. Link, A.; Balaguer, F.; Goel, A. Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics. Biochem. Pharmacol. 2010, 80, 1771-1792. 20. Navarro-Perán, E.; Cabezas-Herrera, J.; Campo, L.S.; Rodríguez-López, J.N. Effects of folate cycle disruption by the green tea polyphenol epigallocatechin-3-gallate. Int. J. Biochem. Cell Biol. 2007, 39, 2215-2225. 21. Yilmaz, Y.; Toledo, R.T. Major Flavonoids in Grape Seeds and Skins: Antioxidant Capacity of Catechin, Epicatechin, and Gallic Acid. J. Agric. Food. Chem. 2004, 52, 255-260. 22. Aggarwal, B.B.; Shishodia, S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71, 1397-1421. 23. Proestos, C.; Sereli, D.; Komaitis, M. Determination of PhC in aromatic plants by RP-HPLC and GC-MS. Food Chem. 2006, 95, 44-52. 24. Proestos, C.; Kapsokefalou, M.; Komaitis, M. Analysis of naturally occurring phenolic compounds in aromatic plants by RP-HPLC and GC-MS after silylation. J. Food Qual. 2008, 31, 402-414. 25. Lin, X.F.; Min, W.; Luo, D. Anticarcinogenic effect of ferulic acid on ultraviolet-B irradiated human keratinocyte HaCaT cells. J. Med. Plants Res. 2010, 4, 1686-1694. 26. Baskaran, N.; Manoharan, S.; Balakrishnan, S.; Pugalendhi, P. Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague—Dawley rats. Eur. J. Pharmacol. 2010, 637, 22-29. 27. Salucci, M.; Stivala, L.A.; Maiani, G.; Bugianesi, R.; Vannini, V. Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2). Br. J. Cancer 2002, 86, 1645-1651. 28. Sohi, K.K.; Mittal, N.; Hundal, M.K.; Khanduja, K.L. Gallic acid, an antioxidant, exhibits anti apoptotic potential in normal human lymphocytes: a Bcl-2 independent mechanism. J. Nutr. Sci. Vitaminol. 2003, 49, 221-227. 29. Kampa, M.; Alexaki, V.I.; Notas, G.; Nifli, A.P.; Nistikaki, A.; Hatzoglou, A.; Bakogeorgou, B.; Kouimtzoglou, E.; Blekas, G.; Boskou, D.; Gravanis, A.; Castanas, E. Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: Potential mechanisms of action. Breast Cancer Res. 2004, 6, 63-74. 30. Murugan, R.S.; Priyadarsini, R.V.; Ramalingam, K.; Hara, Y.; Karunagaran, D.; Nagini, S. Intrinsic apoptosis and NF-κB signaling are potential molecular targets for chemoprevention by black tea polyphenols in HepG2 cells in vitro and in a rat hepatocarcinogenesis model in vivo. Food Chem. Toxicol. 2010, 48, 3281-3287. 31. Way, T.D.; Lin, H.Y.; Hua, K.T.; Lee, J.C.; Li, W.H.; Lee, M.R.; Shuang, C.H.; Lin, J.K. Beneficial effects of different tea flowers against human breast cancer MCF-7 cells. Food Chem. 2009, 114, 1231-1236. 32. Lin, J.K. Cancer Chemoprevention by Tea Polyphenols through Modulating Signal Transduction Pathways. Arch. Pharm. Res. 2002, 25, 561-571. 33. Filomeni, G.; Graziani, I.; Rotilio, G.; Ciriolo, M.R. trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways. Genes Nutr. 2007, 2, 295-305. 34. Yeh, C.T.; Yen, G.C. Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells. Carcinogenesis 2006, 27, 1008-1017. 35. Ma, Z.C.; Hong, Q.; Wang, Y.G.; Tan, H.L.; Xiao, C.R.; Liang, Q.D.; Zhang, B.L.; Gao, Y. Ferulic acid protects human umbilical vein endothelial cells from radiation induced oxidative stress by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways. Biol. Pharm. Bull. 2010, 33, 29-34. 36. Maggi-Capeyron, M.F.; Ceballos, P.; Cristol, J.P.; Delbosc, S.; Le Doucen, C.; Pons, M.; Léger, C.L.; Descomps, B. Wine phenolic antioxidants inhibit AP-1 transcriptional activity. J. Agric. Food Chem. 2001, 49, 5646-5652. 37. Owuor, E.D.; Kon, A.N. Antioxidants and oxidants regulated signal transduction pathways. Biochem. Pharm. 2002, 64, 765-770. 38. Chen, Y.C.; Liang, Y.C.; Lin-Shiau, S.Y.; Ho, C.T.; Lin. J.K. Inhibition of TPA-Induced Protein Kinase C and Transcription Activator Protein-1 Binding Activities by Theaflavin-3,3‘-digallate from Black Tea in NIH3T3 Cells. J. Agric. Food Chem. 1999, 47, 1416-1421. 39. Dhandapani, K.M.; Mahesh, V.B.; Brann, D.W. Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFκB transcription factors. J. Neurochem. 2007, 102, 522-538. 40. Hakimuddin, F.; Tiwari, K.; Paliyath, G.; Meckling, K. Grape and wine phenolic compounds down-regulate the expression of signal transduction genes and inhibit the growth of estrogen receptor—negative MDA-MB231 tumors in nu/nu mouse xenografts. Nutr. Res. 2008, 28, 702-713. 41. Boukamp, P.; Petrussevska, R.; Breitkreutz, D.; Hornung, J.; Markham, A. Normal keratinization in a spontaneously immortalized aneuploid keratinocyte cell line. J. Cell. Biol. 1988, 106, 761-771. 42. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 1973, 65, 53-63. 43. Lee, B.L.; Ong, C.N. Comparative analysis of tea catechins and theaflavins by highperformance liquid chromatography and capillary electrophoresis. J. Chromatogr. 2000, 881, 439-447.
utb.fulltext.sponsorship	This article was created with the support of Operational Program Research and Development for Innovations co-funded by the European Regional Development Fund (ERDF) and the national budget of the Czech Republic, within the framework of the Centre of Polymer Systems project (reg. number: CZ.1.05/2.1.00/03.0111). The work was also supported by a research project of the Ministry of Education, Youth and Sports of the Czech Republic (MSM 7088352101). Author Z. Kuceková thanks the internal grant of TBU at Zlin No. IGA/20/FT/11/D funded from the specific university research resources for support
utb.fulltext.projects	CZ.1.05/2.1.00/03.0111
utb.fulltext.projects	MSM 7088352101
utb.fulltext.projects	IGA/20/FT/11/D