Hodnocení stability n-alkyl derivátů hyaluronátu metodou DSC a TG

Abstract

Termické a termooxidační chování sodné soli kyseliny hyaluronové a jejich n-hexyl, n-tetradecyl a n-hexadecyl derivátů o stejném stupni substituce bylo studováno metodami DSC a DTG. Zjistila se snížená termická stabilita těchto derivátů oproti nesubstituovyným vzorkům, stejně jako nižší hodnoty termodynamicko-kinetických parametrů degradačních procesů.

The thermal and thermooxidative behavior of sodium salt of hyaluronic acid (HA) and its n-hexyl, n-decyl, n-tetradecyl and n-hexadecyl ether derivatives having an equal degree of substitution have been studied by means of differential scanning calorimetry (DSC) and thermogravimetry (TG). Derivatives were prepared by a substitution of H atom at the OH bound to the sixth C of N-acetyl-D-glucosamin of HA unit by n-hexyl, n-decyl, n-tetradecyl and n-hexadecyl chains. Both thermal and thermooxidative degradation of HA and derivatives resulted in multistep process. The main interest of this work was focused on processes occurring in the course of the first decomposition step. Experimental DSC data showed lower stability of derivatives and, remarkably lower heat evolution in comparison with original HA. On the other hand, TG measurement recorded lower mass loss for derivates which indicated appearance of new types of crosslinking reactions. Oxidative stability was evaluated by means of DSC that provided the induction period and the protection factor determination. Derivates showed remarkably lower stability in comparison with original HA

comparing each other, the highest oxidation stability showed n-decyl and n-tetradecyl derivates.